Erythropoietin: function and therapeutic potential

Erythropoietin (EPO) exerts its effect on erythroid lineage cells through interaction with the EPO receptor (EPOR), so-called canonical pathway, and a complex consisting of EPOR common cytokine beta subunit (CD131) – non-canonical pathway for non-hematopoietic human animal body. realizes effects launch signaling cascade, which begins phosphorylation Janus kinase 2 (JAK2) then involvement phosphatidylinositol-3 B (PI3K) or Ras-mitogen-activated protein (MAPK) signal transducers transcription activators (STAT). exhibits direct cytoprotective increased CD131 expression subsequent development anti-apoptotic anti-inflammatory in target cells. In addition to use treatment anemia, is increasingly being used correction inflammatory degenerative processes, both experimental clinical studies. promotes engraftment stem cells, differentiation mesenchymal connective tissue direction, suppresses response apoptosis lesion. The article includes literature data concerning based from eLibrary National Center Biotechnological Information (NCBI) period 1998–2022.